NFL picks, predictions Week 6: Experts favor 49ers over Seahawks on Thursday Night Football
" The 49ers rank second in the NFL in yards per game (407.4), but they are 0-2 S/U on the road. San Francisco has struggled in the red zone on offense. Will a Seattle defense that has allowed 35.5 points per game in losses to the Lions and Giants the past two weeks be the cure? Seattle is 1-4 ATS this season. "